We look every day to find "useful things" that enable minorities to live without suffering! Headline: New target for possible HIV treatment discovered

We look every day to find "useful things" that enable minorities to live without suffering! Headline: New target for possible HIV treatment discovered Researchers from Austria have been able to identify a previously unknown mechanism of the HI virus, which plays a central role in replication in the human body. Innsbruck (Austria). Although medicine has made enormous advances in the treatment of AIDS in recent years and HIV can be treated better and better, the infectious disease is still not completely curable. Although doctors have been able to heal a few people with AIDS, comprehensive treatment of all those affected is not yet possible for various reasons. Kathrin Breuker and her colleagues from the Institute of Organic Chemistry at the University of Innsbruck have now made a completely new discovery: they have discovered a previously unknown mechanism that plays a central role in the multiplication of the HI virus in the human body. In concrete terms, this means that the researchers have found a new binding site that could be of interest for future therapies. Physicians and scientists worldwide are searching for more efficient therapies to treat AIDS. The focus of research is primarily on combating the virus, but also on mechanisms that prevent it from multiplying. In order to settle in the body, the HI virus penetrates human cells and builds its genetic information into the cell nucleus of the DNA. In this way, modified mRNA is produced, which gets from the cell nucleus into the cell fluid and changes proteins there in such a way that they serve virus replication. Stop the HIV virus from multiplying In order for the virus mRNA to be able to leave the cell nucleus quickly, it needs eight to ten molecules of a very specific protein (rev). So far, however, it was completely unclear where exactly on the RNA and also in which order the rev proteins attach themselves. However, if you understand this process exactly and have the knowledge about the attachment, you can stop the virus from multiplying. With the help of a completely new method, the researchers have examined the replication mechanism of the virus more closely and discovered a new binding site. The rev proteins are captured at it and forwarded to binding sites that have been known for some time, which in turn enables the formation of stable RNA-protein complexes. It is precisely at this point that future therapies could start and interrupt the multiplication of the HI virus in the body. As the researchers report in the journal Nature Communications, the new research results are not only interesting with regard to new AIDS therapies, they also explain older research results, which were previously not or only partially understood. In the circles of activists, the motto is, we never give up, because hope dies last. Greetings Nikita Noemi Rothenbacher